Research Groups and projects

Atherosclerosis and vascular biology

Head: Prof. Dr. med. Katrin Schäfer

The working group investigates the molecular mechanisms of increased cardiovascular risk due to obesity, focusing on the effect of the adipokin Leptin on vascular cells (including endothelial progenitor cells) and platelets in vitro and in vivo.
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Cardiovascular experimental electrophysiology and imaging

Head: Prof. Dr. Gerd Hasenfuß

Our group is funded by several grants, including an SFB 1002 A11 project grant from the Deutsche Forschungsgemeinschaft (DFG) entitled “Irregular ventricular activation - a novel mechanism impairing Ca2+-homeostasis and excitability in the transition to heart failure“. This project aims at investigating the effects of atrial fibrillation on ventricular calcium cycling.
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Clinical electrophysiology

Head: Prof. Dr. Markus Zabel

Besides the care for patients suffering from arrythmias, this mainly clinically oriented working group performs all kinds of pacemaker and defibrillator implantations.
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Hypoxia research

Head: Prof. Dr. med. Dörthe M. Katschinski

High altitude and various cardiovascular diseases have a limited oxygen supply in common. The molecular mechanisms of hypoxia sensing and its therapeutic consequences are investigated in the Department of Cardiovascular Physiology.
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Innovative Clinical Trials

Head: Prof. Dr. Dr. med. Stefan D. Anker

The main focus of the Innovative Clinical Trials is the research in the field of chronic heart failure. The development and clinical testing of new therapies prioritize in this connection. Both areas are developed on the basis of pathophysiological comprehension.
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Interventional Cardiology I

Head: Dr. Claudius Jacobshagen

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Interventional Cardiology II

Head: PD Dr. Wolfgang Schillinger

The working group investigates and implements new minimal-invasive catheter-based interventional procedures to treat heart diseases. Its goal is to optimize the treatment of risk patients in accordance with highest possible quality and safety standards.
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Cardiac Remodeling

Head: Prof. Dr. med. Karl Toischer

Our research is focused on the process of cardiac remodeling.
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Cardiac Stroma

Head: Prof. Dr. med. Elisabeth Zeisberg

Focus of our research team is the pathomechanism of cardiac fibrosis, a pathologic scarring process which occurs in all forms of chronic heart disease, and which contributes to heart failure. Our approach is to transfer clinical analyses into animal models and cell culture experiments to thus gain mechanistic insights into the pathophysiology of heart fibrosis.
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Cardiovascular cell biology and systems medicine

Head: Dr. rer. nat. Antje Ebert

We are studying the cell biology of cardiovascular disease mechanisms, utilizing a human model system of patient-specific, induced pluripotent stem cells (iPSCs), in combination with site-specific genome editing, as well as biochemical and systems biology approaches. 
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Head: Prof. Dr. med. Stefan Andreas

There is an established, longstanding cooperation between the Lung Clinic Immenhausen and the Department of Cardiology and Pneumology at the University Medical Center Göttingen (UMG). Hence Prof. Dr. Stefan Andreas as head of the Lung Clinic is leading the section of Pneumology at the UMG.
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Molecular and Translational Vascular Medicine

Head: Dr. med. Uwe Raaz

Our research group at the Heart Research Center Göttingen focuses on the role of biomechanics and (epi-) genetics in the vascular aging process and in the development of cardiovascular diseases (such as heart failure, hypertension, stroke, or aneurysm formation).
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Molecular cardiology

Head: Dr. med. Tim Seidler

The working group studies the molecular mechanisms of signal transduction in cardiomyocytes. Its main objective is to investigate signalling pathways which control the development of hypertrophy and heart failure.
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Pediatric cardiology

Head: PD Dr. med. Matthias Sigler

The research activities of the Department of Pediatric Cardiology and Intensive Care Medicine focus on three different projects:
1. Biocompatibility examinations of cardiovascular implants
2. Effects of the application of cryo energy on the growing myocardium
3. Metabolic modulation and molecular regulation of the cardiac energy metabolism in children with cyanotic cardiac defects
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Head: Prof. Dr. med. Christoph Herrmann-Lingen

The working group deals with the research of the bi-directional relations between psycho-social factors on one hand and cardiovascular functions, diseases, and discomfort on the other.
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Translational stem cell research

Head: Dr. rer. nat. Katrin Streckfuß-Bömeke

Our research group focuses on the pathomechanisms during the development of cardiovascular diseases (such as dilated cardiomyopathy, anthracycline-induced cardiomyopathy and Takotsubo cardiomyopathy) by using translational cellular models as patient-specific induced pluripotent stem cells, human cardiac fibroblasts and human cardiac tissue from patients with heart disease.
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Stem Cell Unit

Head: Dr. rer. nat. Lukas Cyganek

The Stem Cell Unit - Göttingen is a non-commercial scientific unit at the UMG and provides support for research and education in the fields of stem cell research to the scientific community in Göttingen and to research institutes within the DZHK.
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Translational cardiology

Head: Prof. Dr. Stephan Lehnart

Main research: Molecular mechanisms of myocardial function and myocardial diseases which lead to arrythmias and cardiac remodeling.
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EU Project: EUGeneHeart

Head: Prof. Dr. Gerd Hasenfuß

From 2006 until 2010, the Heart Center Göttingen coordinated one of the largest heart research projects funded by the EU.  More than 20 research groups from 10 European countries participated in this project. It dealt with the detection of the mechanisms leading to heart failure, and the development of new treatments. The grown European network continues to pursue further approaches to prevent and treat heart failure beyond the official end of the project.
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EU Project: EUTrigTreat

Head: Prof. Dr. Stephan Lehnart

This project funded by the EU investigates the causes and risks of arrythmias.
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