Project Area A) Functional Microdomains

TP A01 cAMP and cGMP microdomains in cardiac hypertrophy and failure

TP A01 studies functional connections of β1/2/3-adrenergic and M2-muscarinic receptors with subcellular cAMP- and cGMP-microdomains using the newly developed SICM/FRET technique.

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TP A02 Relevance of phosphatase-inhibitor-1 for SR-specific modulation of the β-Adrenozeptor cascade

TP A02 studies phosphatase-inhibitor-1-mediated phosphorylations within the functional Ca2+-re-uptake and Ca2+-release-microdomains of the sarcoplasmic reticulum (SR) through dual regulation of phospholamban and ryanodine receptors.

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TP A03 Effects of CaMKII on arrhythmogenesis in heart failure

TP A03 evaluates CaMKinase-dependent regulation of sarcolemmal sodium channel and sarcoplasmic reticulum ryanodine receptor microdomains. Interaction of...

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TP A04 Functional analysis of ryanodine receptor mutations using patient-specific induced pluripotent stem cells

TP A04 utilizes the induced pluripotent stem (iPS) cell technology to study the role of distinct ryanodine receptor (RyR) mutations as a model of the sarcoplasmic reticulum calcium leak in terms of arrhythmias and heart failure.

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TP A05 Molecular imaging of cardiac calcium release units

TP A05 applies novel super-resolution imaging strategies to an essential nanodomain of heart muscle cells, the cardiac calcium release unit.

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TP A06 Heart failure in mitochondrial cardiomyopathies examplified by the Barth syndrome

TP A06: Barth Syndrome includes a dilatative cardiomyopathy, caused by defective cardiolipin biosyntheses. Cardiolipin is a mitochondria-specific lipid with a central role for the formation of functional microdomains in the inner membrane.

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