Project Area B) Sensor Complexes

TP B01 ATP-sensitive potassium (KATP) channels as cellular energy sensors

TP B01 addresses the role of ATP-sensitive potassium (KATP) channels as cellular energy sensors. In particular we ask how subunit composition, protein interaction partners and...

read more

TP B03 Mechanosensor complexes at the cardiac titin springs

TP B03 investigates segments of the giant elastic sarcomere protein titin and their interaction with structural and signaling proteins as potential mechanosensor complexes at elevated loads.

read more

TP B04 Mechano-Signaltransduction in preload versus afterload

TP B04: We could previously show that afterload leads to maladaptive hypertrophy and heart failure whereas preload with comparable elevation of wall stress leads to adaptive hypertrophy.

read more

TP B05 Allosteric regulation of ryanodine receptors in arrhythmias and heart failure

TP B05 characterizes the cardiac calcium release channel/ryanodine receptor (RyR2) as physiologically important sensor complex and as molecular heart rate regulator.

read more