Project Area C) Cell-Cell-Communication

TP C01 Epigenetic control of cardiac fibrosis

TP C01 elucidates how epigenetic modifications lead to the cellular event of endothelial-mesenchymal transition, and ultimately contribute to progression of cardiac fibrosis.

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TP C02 Relevance of RhoGTPases for load-induced cardiac fibrosis

TP C02 investigates the role of RhoGTPases for load-induced cardiac fibrosis. Thereby, we focus on the guanine nucleotide exchange factor p63RhoGEF, which has been shown by the working group to be a direct ...

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TP C03 Arrhythmogenic remodeling of multicellular substrates

TP C03 Low-energy Anti-Fibrillation Pacing (LEAP) terminates ventricular tachycardia and fibrillation with 80-90% less energy than conventional defibrillation shocks.

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TP C04 Control of myocardial micro environment through fibroblasts

TP C04 studies fibroblast-cardiomyocyte interactions in the heart to test the hypothesis that fibroblast dysfunction is a primary and/or secondary cause for load-induced heart failure.

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TP C05 Role of cellular immune reactions for cardiac remodeling and therapy of heart failure by stem cell transplantation

TP C05: Previous results indicate that increased preload in contrast to increased afterload is associated with cardiac inflammation and autoimmunity.

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TP C06 Mechanisms and regulation of coronary angiogenesis

TP C06. The aim of this project is to examine the importance of coronary angiogenesis for myocardial capillary density and fibrosis during the development of cardiac hypertrophy and failure.

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TP INF Electronic lab book to data base - flexible metadata annotation as the basis of modern data management

TP INF provides an IT-infrastructure for structured data management and preservation.

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TP S Service unit intervention and cell models

TP S provides well established models of load-induced hypertrophy/heart failure by transaortic constriction (TAC) and aortocaval (shunt) operation as well as...

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TP Z Central organization and government

TP Z is coordinated by the manager of the SFB 1002 under the guidance of the SFB speaker.

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